M.D.​​ Hladchuk​​ V.Ye.
Hladchuk Medical ​​Aesthetic​​ Centre,​​ Kiev, ​​Ukraine.


The main point of exploration is an establishment of cosmetological defective
influence and skin itch on psychovegetative syndrome among chronic eczema
patients. Following this aim the electroencefalogram method was principal. 40
chronic eczema patients were examined. According to the psychological
investigation and the main exploration the psychovegetative syndrome showed
up leading some define bioelectric brain activity changes that can prove an
advantage of limbico-reticular disfunction complex (according to EEG).
Observational datas are persistent enough to allow the newest development of
brain restorative and dilatory module systems.
Key words — eczema, psychological investigation, electroencefalogram.


Different medical specialists are found of solving the
developing psychovegetative problem in eczema patients. There are two
highlighted methods of diagnostic — EEG and REG (mostly known as
electroencefalogram and radioencefalogram). The medical literature
misconcepts the role of limbic-reticular structural complexes in the changes of
brain indicators in functions that are registered by the EEG, the value of the
interhemispheric asymmetry with regulative psychovegetative disorders. It is
especially true when the structure of diseases changes, the origin of which is due
to psychologic disorders and highlights the modern features of the
vegetative-vascular dystonia syndrome,which is often found in the neuroses.

The ​​purpose ​​of the study is to estimate the values of changes in bioelectrical
activity of the brain (using EEG) as an objective criteria of clinical
manifestations psychovegetative syndrome of dermatological origin.

​​Materials​​ and ​​methods​.

The study included 40 male patients with clinically
detected signs of eczematous process and psychovegetative syndrome. The
bioelectric brain activity studies was performed on 10-channel EEG machine
NIHON KONDEN-7300 (Japan). The placing of electrodes on the head surface
was carried out in the so-called «10-20 system» (Ten-Twenty System), which is
recommended by the international Federation of EEG and clinical
electrophysiology. Conducting EEG studies have measured changes in the
bioelectric brain activity according to this exact algorithm:
1)the main symptoms that highlight the General properties of the pattern (main
EEG components, amplitudes, characteristics of alpha activity, regional
differences, beta activity low frequency, Delta-activity, biopotential field
2)Clarified the type, group, class, nature, extent of EEG deviations from the
norm on the background bioelectric activity, evaluated the reactivity pattern.
The total valuation of psychophysical status is presented by special survery that
permits clear analysation of depression that are showed in such ICD-10 columns
as F06.3, F32, F33, F34, F43.2.
Obtained results purpose of which is to get trustworthy datas processed
personally on PC (LP “Statistica 6.0”).


Result s​​and ​​discussion.​​

Each patient was diagnosed with typical eczema
markers which include symmetrical localisations of affected areas (face, limbs,
trunk), blurred lines and alternation of affected skin surfaces, itch. The middle
grade of depression elicited in 95%, other 5% — hidden forms of it (latent). At
the same time such clinical symptoms as somatic sleep disturbance, appetite and
potency decreasing, mood fluctuations are often marked as psychovegetaive
syndrome. Eczema victims are often suffer from non-synchronization of sleep
biorhythms, season intensifications, panic attacks. According to obtained results
that are mentioned on the picture, The First EEG type organized “in space and
time” marked in 17,5% of time which is to be exact is p<0.001 happens rarely
than in healthy people (58,3%). The second hypersynchronous or
monorhythmical type was diagnosed less often than in healthy people as well —
7,5%(p<0.01) versus 16,7%. The third desynchronous type was not found at all.
The fourth disorganized with main a-activity registered exactly more often than
in patients p<0.001 or 57,5% to 16,7%. The fifth type is disorganised with
maining theta- and delta-activity was noticed in 17,5% of patients but it was not
diagnosed in healthy people. Patients with “biopsy itch” (17,5%) were
concluded with typical “epileptiform” pattern on EEG.
EMBED MSGraph.Chart.8 \s
Pattern — EEG in healthy affected people, reliability markers (p) that are
mentioned in the text.
Obtained results give us evidence of fact that in cases of developing
depression in eczema victims delta- theta- activities are increasing and alphaand
betta- activities are lowering. Also the regional lowering differences
between superior and inferior part of the brain and increasing activity of the
right hemisphere inverse the left were remarked. Under emotional influences
which firstly include cosmetic defect on the skin surface functional system is
forming enclosing lowering of the brain educations which provides the the best
implementation of this sensory activity — under the pressure of negative
emotions internal and interhemispheric cross correlation coefficients are falling.
In fact this motivationally-emotional and vegetative reactions of the integral
human are united in one functional block and so this is not an accident that
limbic system is marked as “emotional” and “visceral” brain. If healthy person
is energetically provided by appropriate vegetative accompaniment in
pathological cases the psychovegetative condition takes place inside of which
emotional and inadequate (the lowest or the highest) are retaining. The stage of
the limbic disorganisation reflects the adaptative level which is provided by
limbic-reticular complex. This disorders display some dominative fenomens like
anxiety, depression, hypohondria, astheny, hysteria [201, 203, 206, 207, 208].
Two types of brain homeostasis modifications (activating or synchronizing)
where are some violations of descending and ascending reticular formation
systems take place are factors of the vegetative dysfunctions pathogenesis of
nonspecific brain systems [165, 171, 176, 181, 182, 185, 190, 194, 197, 199].
All mentioned examples define some sorts of disorientation like intrasystemic,
intersystemic, interhemispheric disbalances. And at the same time the violation
mechanism of integrative brain activity projects as vegetative vessels
conducting at the frustration segment and it is more difficult in comparison
with mechanisms of irritation and destruction which are main characteristic for
segmentary vegetative vessels frustration.
As the leading factors which cause psychovegetative mental syndrome, the role
of acute and chronic emotional stress is obvious. Emotional frustration is the
main factor which defines violations of normal nonspecific systems functioning
of a brain and causing changes of integrative activity (the disintegration


Conclusion. ​​

Patients with true chronic eczema who have an appearance of rash
and skin surface itch are often have psychovegetative syndrome with bioelectric
activity changes as well (according to EEG). Disturbances in the regulatory
brain systems (first of all – a limbiс-reticular complex) considerably is
influenced by factors of a skin damage (existence of cosmetic defect and an
intensive itch). The perspective of further studies is an exploration of generative
activation and inhibition mechanisms in certain regulative centers in the brain
systems and developing of new effective methods of complex therapy that will
allow modulation of influence balance in activation and inhibition systems in
eczema patients.


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